The Andromeda spam botnet is a good example of this trend, this time with aid of the Blackhole Exploit kits (BHEK) and some new neat tricks. This threat arrives as a spammed message containing a malicious attachment (GAMARUE variants) or links leading to certain sites, which now include those compromised by the notorious Blackhole Exploit kit. Some of the commands the malware can execute include downloading other malware onto the system, most notably info-stealing threats like ZeuS/ZBOT variants.
Because some Andromeda-related spam messages eerily looks like legitimate email notification from commercial services (flight, hotel, courier services etc.), the usual criteria for determining a spam are not sufficient. Since BHEK is known to exploit software vulnerabilities like Java, you must always update your system with the latest security patch or re-consider your use of Java. For better protection, install antimalware software like Trend Micro, which protects your system from spam, malicious URLs, and malware.