Supply chain security is being remade by black swan events, economic blahs, and more. What can a CSO do to keep goods and information flowing? As any CSO knows, it’s not enough to mind your own business. You have to look after your business partners as well, across all links that connect to your supply chain—whether that chain is physical or virtual. And that goes double in times of rapid change and high stress. “The threat environment is constantly changing,” says Ryan Brewer, CISO for the Centers for Medicare and Medicaid Services “Sometimes it’s hard to put your finger on what’s most important.” Who would have thought three years ago that piracy on the supply chain would be such a big concern? Sometimes the big worry is terrorism, sometimes it’s natural disasters, lately it’s malware. Here are the top five developments CSOs say have the biggest potential to wreak havoc on their supply chains.